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“ Folate conjugation unexpectedly allowed the self-assembly of heparin , where a majority of the folate molecules (>80%) resided inside the core of the nanoparticle.”
“It was estimated that heparin bound several orders of magnitude less strongly than folate with an average dissociation constant in the 1–10 μM range.”
“ Folate blocks the increases in the phosphatase activity and in the excretion of choline that are ordinarily produced by a mixture of glycine and heparin or by cortisol.”