Possible Interaction: Heparin and Fat Emulsion

“Indirect calorimetry was performed continuously in healthy male subjects receiving a constant infusion of fat emulsion (0.2 g min-1) and glucose (…) or LMWH (n = 6) (100 antifactor Xa units kg-1) or saline (n = 6) was given over 1 h. Plasma concentration of the fat emulsion … heparin …).”

“The authors recommend a wider use of fatty emulsions with heparin and intraarterial infusion of agents in the generally accepted complex of therapeutic measures.”

“ Heparin injected … a fat emulsion raised FFA levels acutely from 0.4 +/- 0.1 to near 3 mmol/L. Plasma somatostatin-like immunoreactivity (SLI) rose from a … 9.2 +/- 1.0 ng Eq S14/L to 20.0 +/- 6.0 ng Eq S14/L (P less than 0.05).”

“In another group of anesthetized dogs … implanted catheters the administration of fat emulsion … heparin was accompanied by more than a two-fold rise in the concentration of SLI in the venous effluent … the pancreas and of the gastric fundus and antrum in association with an elevation of FFA levels.”

“In … dogs fat emulsion … heparin raised FFA from a mean base-line level of 1.2+/-0.2 to 1.6+/-0.3 meq/liter (P < 0.… a mean base-line level of 185+/-9 pg/ml to a peak value of 310+/-44 pg/ml (P < 0.01).”

“… heparin … fat emulsion elevated FFA levels from a mean (+/-SE) base-line level of 0.7+/-0.1 meq/liter to a peak value of 1.… from a mean (+/-SE) base-line value of 145+/-7 pg/ml to a peak of 253+/-44 pg/ml (P < 0.05).”

“In one group of eight hearts, treatments with heparin and 10% fat emulsion (Intralipid) produced a 3- to 5-fold elevation in serum FFA levels as contrasted with levels in 10 untreated hearts.”

“Addition of heparin to intravenously administered fat emulsion in rats resulted in a marked increase in the rate of disappearance of the fat from the blood and a decrease in the accumulation of fat in the spleen and liver.”

“Injection of heparin with fat emulsion resulted in higher serum hemoglobin levels than injection of fat emulsion alone but this difference was seen only when the blood was allowed to stand for a period after it had been drawn.”