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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heparin
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Interestingly, the interaction of an octapeptide-spanning peptide motif amino acids 53–93 with heparin is enhanced by Cu(II) ions.”
Identification of the Heparan Sulfate Binding Sites in the Cellular Prion Protein*“A free radical reaction generated by a mixture of Cu2+ , hydrogen peroxide, and ascorbate causes an abrupt reduction in the anti Xa activity of heparin by about one-half, and in molecular weight by about one-third.”
“Overall, the results are more consistent with a high degree of regioselectivity in the interaction between heparin and Cu2+ ion , than with a delocalized counter-ion interaction.”
Evidence of a selective free radical degradation of heparin, mediated by cupric ion.“The metal ions Cu2+ , Zn2+, Fe2+ and Fe3+ inhibited heparin binding, with half-maximal inhibition of binding to lactoferrin occurring between 600 microM and 1 mM and for lysozyme between 500 and 800 microM. 3.”
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