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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Heparin and Calcium Supplement

Research Papers that Mention the Interaction

Heparin leads to a concentration-related reduction of calcium ions in blood.
Zentralblatt fur Veterinarmedizin. Reihe A  •  1991  |  View Paper
The initial rate of thrombin (4.0 nM) inhibition by antithrombin III (200 nM) in the presence of heparin (2.5 ng/ml) decreased from 3.6 nM/min (in the absence of calcium) to 0.12 nM/min in the presence of 10 mM calcium.
Archives of biochemistry and biophysics  •  1983  |  View Paper
Heparin stimulated calcium sensitive gelatinolytic activities of approximately 22, 42, and 60kDa, but did not affect activities of MMP-2, MMP-9, or the 75kDa caseinolytic activity.
Experimental and molecular pathology  •  2017  |  View Paper
These antibodies or calcium selectively modulate interactions of fibronectin, heparin , sulfatide, alpha3beta1 integrin, tumor necrosis factor-alpha-stimulated gene-6 protein, and, to a lesser extent, alpha4beta1 integrin with native thrombospondin-1 but not with the truncated protein.
Matrix biology : journal of the International Society for Matrix Biology  •  2008  |  View Paper
Binding of a full-length heparin chain to this site of factor Xa in the presence of calcium makes a significant contribution to acceleration of the proteinase inhibition by antithrombin through a ternary complex bridging or template mechanism.
Trends in cardiovascular medicine  •  2000  |  View Paper
Heparin (200 UI/mL) decreased the free calcium concentration in Tyrode solution to 0.8 mM. Such a lowering of the free calcium concentration diminished vascular contractile reactions.
Ginekologia polska  •  1998  |  View Paper
CONCLUSION Zinc he arin pr oduces a significant positive bias in the simultaneous determination of ionized magnesium and ion ized ca lcium concentrations.
Clinical biochemistry  •  1995  |  View Paper
However, the presence of calcium in EB heparin significantly increased measured total calcium concentrations, whereas the new CNLZ heparin did not interfere in total calcium determinations.
Clinical chemistry  •  1994  |  View Paper
In a … mixture containing calcium ions and approximately equimolar concentrations of relipidated tissue factor (8.9 nmol/L) and factor VIIa (10 nmol/L), AT III (100 micrograms/mL) plus heparin (1 U/mL) inhibited 50% of the factor VIIa coagulant activity of the reaction mixture within 5 minutes.
Blood  •  1993  |  View Paper
More importantly, heparin abolished GTP gamma S (2.5 microM) induced Ca2+ release (IC50 10 micrograms/ml).
Thrombosis research  •  1992  |  View Paper
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