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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Heparin and Ascorbate

drug:

Heparin

supplement:

Ascorbate

Research Papers that Mention the Interaction

In the presence of heparin, ascorbate plus iron elicited a long-lasting activation of the channel which had conductance gCa2+ = 100 pS characteristic for the ryanodine receptor and which could be blocked by the ryanodine channel inhibitor, ruthenium red.
Archives of biochemistry and biophysics  •  1994  |  View Paper
A free radical reaction generated by a mixture of Cu2+, hydrogen peroxide, and ascorbate causes an abrupt reduction in the anti Xa activity of heparin by about one-half, and in molecular weight by about one-third.
Carbohydrate research  •  1994  |  View Paper