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“In addition, co‐treatment of cells with hemin and retinoid led to longer maintenance of the differentiated state after the removal of hemin, which might imply aquisition of irreversibility of hemin‐induced differentiation.”
“ ATRA increased the number of these colonies in a concentration-dependent manner, with maximal … the presence of 5.5 ng/ml IL-3, 0.1 mM hemin , 3.0 U/ml Epo and 30 nM IGF-I. This … activity of two metabolic derivatives of vitamin A in SF medium.”