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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hemin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions.”
Functional binding analysis of human fibrinogen as an iron- and heme-binding protein“Pretreatment with hemin and desferoxamine, which, like ferritin, can bind iron , inhibited H(2)O(2)-induced increases in G and mannitol permeability.”
“Iron utilization studies of selected citrobacter isolates indicated that hemin and hematin could reverse the effects of iron limitation on growth under iron-stressed conditions (1000 micrograms/ml of EDDA).”
“ Hemin treatment led to augmented HO expression and activity in association with increased iron accumulation and oxidative stress.”
Heme-oxygenase-mediated iron accumulation in the liver.“Experiments carried out with 55Fe(HQ)2 showed that iron uptake capacity of cells was greatly enhanced after hemin treatment.”
“Addition of a large excess of iron as hemin resulted in an eight-fold increase in ferritin concentration.”
“ Hemin inhibited transferrin iron uptake and heme synthesis, but had a much lesser effect on iron incorporation and heme synthesis from non-transferrin donors of iron.”
“ Hemin inhibits Tf-bound iron uptake by DMSO induced cells but not by the uninduced cells.”
“Addition of hemin to reticulocytes inhibits incorporation of iron from transferrin [Ponka, P. & Neuwirt, J. (1969) Blood 33, 609-707].”
“ Hemin reduced the initial influx of transferrin, thereby diminishing incorporation of iron.”
“The possibility that hemin influences mainly the uptake of iron used directly for heme synthesis, and to a lesser extent intracellular storage of iron is discussed.”
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