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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Hemin and Folate

drug:

Hemin

supplement:

Folate

Research Papers that Mention the Interaction

Although thiamine pyrophosphate (TPP), a substrate of RFC, had no effect on folate uptake, hemin (a weak inhibitor of folate uptake via HCP1) decreased folate uptake to about 80% of the control level under an acidic buffer condition.
Furthermore, kinetic analysis showed that hemin inhibited the low-affinity phase of folate uptake under an acidic buffer condition.
Bioscience, biotechnology, and biochemistry  •  2008  |  View Paper