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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hemin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Attempts to characterize this quasi-lipoxygenase activity revealed that calcium potentiated the quasi-lipoxygenase activities of hemoproteins (hemoglobin, myoglobin, myeloperoxidase, catalase, cytochrome c) and hemin at the physiological pH of 7.5.”
Calcium is required for quasi-lipoxygenase activity of hemoproteins.“In response to hemin limitation and in the presence of calcium there was a moderate increase in recA promoter activity.”
“Furthermore, hemin suppressed phospholipase C activity, attenuated inositol 1,4,5-triphosphate, and reduced resting intracellular calcium in the aorta.”
Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension“ Hemin abated PLC activity (29.6±1.5 nmol/min/mL versus 3.1±0.9 …/mL; n=5, P<0.01) and this was accompanied by depleted levels of intracellular calcium (551±46 nM versus 103.2±6.3 nM; …, P<0.01) in the aorta of SHR.”
Interaction between the heme oxygenase system and aldosterone in hypertension.
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