Possible Interaction: Halothane and Tubocurarine

“Thus, 3.3 times as much d-tubocurarine was needed to produce a 50 per cent depression of twitch height with halothane.”

“Histamine release by d-tubocurarine was significantly reduced by 2% halothane compared to d-tubocurarine alone (2.8% +/- 0.9 vs. 13.9% +/- 3.7, mean + SEM) (P less than 0.05) in the in vitro preparation.”

“The blood pressure and pulse rate were maintained even when halothane was employed with pancuronium, d-tubocurarine on the other hand caused hypotension which was more severe in the presence of halothane.”

“In South African pigs halothane can initiate the syndrome in the presence of neuromuscular block produced by tubocurarine (Harrison, 1971), and we were able to produce the syndrome in our known reactors given this relaxant, although in these animals the course of the reaction was modified.”

“REVIOUS REPORTS concerning the anP esthetic combination of Fluothanee halothane ) and d-tubocurarine have indicated the need for further study of the cardiovascular changes which occur in response to this combination.”

“After the application of DTC 10 (-6) M the addition of 0.5% and 1% halothane decreased tau to 52.4% +/- 7.6% and 30.0% +/- 5.9% of control.”

“Combination of tubocurarine with fluothane had a less pronounced inhibitory effect on the activity of Ca2+-ATPase than the components used separately.”

“ Halothane and thiopentone potentiated the hypotensive action of tubocurarine.”

“However, in the report by Watland 1 it is apparent that the intensity and duration of block by tubocurarine was increased in the presence of halothane anesthesia.”

“A report by M. Johnstone on the cardiac effects of fluothane in 500 cases4 gives a salutary warning that hypotension and bradycardia must be expected if concentrations reach as high as 2-4%, and similarly it may prove dangerous if combined with D.tubocurarine.”