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Last Updated: 3 years ago

Possible Interaction: Halothane and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

Quinidine combined with halothane decreased AP amplitude, and prolonged both AP duration to 90% repolarization and conduction (P < 0.05).
Anesthesia and analgesia  •  1992  |  View Paper
It is concluded that quinidine and halothane act synergistically to decrease action potential amplitude, lower RMP, and prolong conduction.
Severe depression of conduction often progressed to conduction block or inexcitability when halothane , 2%, was administered during superfusion with therapeutic concentrations of quinidine.
Synergistic interactions between halothane and quinidine were found on RMP, APamp, APD100, and CT.
Anesthesiology  •  1986  |  View Paper