Possible Interaction: Halothane and Potassium

“The resulting potassium current showed outward rectification under physiological conditions and slight inward rectification with symmetrical high-K+ solutions and could be inhibited by application of halothane or quinidine.”

“ Halothane is a strong inhibitor of potassium evoked spreading depression (SD) in cats.”

“While the levels of catecholamines and potassium decreased already during halothane exposure, haematocrit values and concentrations of glucose and lactate continued to increase.”

“Conclusions Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different.”

“Using the whole-cell patchclamp technique, we have found that application of clinical concentrations of inhalational anaesthetics halothane and isoflurane) and barbiturates depresses whole-cell calcium currents and potassium currents in a concentration-dependent manner.”

“In contrast, the vasodilating actions of halothane and enflurane in the presence of high Potassium sup + appears to involve inhibition of Calcium2+ activation of contractile proteins as well as a decrease in intracellular Calcium2+ concentration in smooth muscle.”

“Our results show that the action potential was prolonged and its plateau was depressed; and that there was a significant inhibition of a potassium current, Ik, and a Ca2+ current, Isi, following halothane (2%) application.”

“ Halothane potentiates GABAA and increases potassium leak conductances.”