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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ Halothane , isoflurane and sevoflurane dose‐dependently inhibited NADH :DBQ oxidoreductase activity.”
“In addition to inhibiting NADH oxidation, halothane also inhibited succinate oxidation (and succinate dehydrogenase), albeit to a lesser extent.”
Halothane, isoflurane and sevoflurane inhibit NADH: ubiquinone oxidoreductase (complex I) of cardiac mitochondria“These results suggest that the mechanism by which halothane inhibits lipogenesis from glycogen or lactate is by inhibition of the oxidation of NADH ; this results in inhibition of flux of carbon through pyruvate dehydrogenase and a shortage of acetyl-CoA for fatty acid synthesis.”
“Thus when NADH acceptors are added in the presence of halothane , the concentration of mitochondrial NAD+ is raised so that the flux of carbon through pyruvate dehydrogenase increases and lipogenesis is restored.”
“It has been previously noted that much higher levels of halothane (per mg mitochondrial protein) are required to inhibit NADH oxidation in submitochondrial particles 161.”
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