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“Chloroform (7.5 – 75 mM) and halothane (1.8 – 18 mM) were found to decrease Mg 2 + ATPase and Ca 2+ ATPase activities, whereas e0her (42.6 – 71 mM) depressed only the Mg 2+ ATPase activity.”
“Recent studies using skinned muscle fibers from MH-susceptible patients suggests that reduced Mg 2 + concentrations may influence the effect of halothane on Ca 2+ release and so have a clinical role in the development of an MH reaction.”