Possible Interaction: Haloperidol and Yohimbine

“Moreover, in rats treated with haloperidol for 10 days, the effect of yohimbine on striatal homovanillic acid and acetylcholine levels was markedly reduced.”

“ Yohimbine failed to further enhance striatal homovanillic acid levels in animals pretreated with a supramaximal dose of haloperidol.”

“ Yohimbine diminished the activity of the extract in the acetic acid test meanwhile haloperidol enhanced its effect.”

“Administration of either the alpha-2 adrenoreceptor antagonist yohimbine (0.1 to 1.0 mg/kg) or the dopamine receptor antagonist haloperidol (1 to 5 mg/kg) caused a partial reversal ofl-dopa-induced protection but not the protective actions of subcutaneous cholecystokinin (100 μg/kg).”

“Antagonism studies were conducted using the selective 5-HT1A receptor antagonist …-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide dihydrochloride (WAY100635).ResultsIdazoxan, efaroxan, and yohimbine significantly … haloperidol (2.5 mg/kg, SC) in the CLP test and the actions … significantly blocked by pre-treatment with WAY100635 (0.63 mg/kg, SC).”

“Prior treatment with haloperidol (1 mg/kg), D1/D2 receptor antagonist haloperidol, sulpiride (50 mg/kg), a selective D2 receptor antagonist, yohimbine (5 mg/kg), a alpha2-adrenoreceptor antagonist but not by SCH 23390 a, selective D1 receptor antagonist blocked this response.”

“The M1 antagonist scopolamine and α2 antagonist yohimbine were able to reduce the catalepsy induced by HP and HP+Δ9‐THC in a similar manner.”

“Injection of haloperidol simultaneous to an effective dose of yohimbine , blocked the ability of the latter to reverse sexual satiation.”

“Pretreatment with high dose of yohimbine (0.5 mg/kg), haloperidol , cyproheptadine, atropine and a combination of atropine and yohimbine significantly reversed the activity.”

“ Yohimbine (2.5 mg/kg) also enhanced memory retrieval, as shown by haloperidol.”

“The dose-dependent diuretic effect of 1 or 10 mg/kg haloperidol was significant from 4 hr afterward, and the haloperidol-induced diuresis was prevented by pretreatment with phenoxybenzamine, prazosin or yohimbine.”