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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Haloperidol
supplement:
Vitamin C
Research Papers that Mention the Interaction
“While haloperidol was significantly more effective than ascorbic acid , the combination was significantly more effective than either used alone.”
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.“Catalepsy induced by haloperidol (0.25 mg/kg IP) was attenuated by ascorbic acid (50–200 mg/kg IP) while pentobarbitone (20 mg/kg IP)-induced sleep in rats was dose-dependently antagonised by ascorbic acid (50–400 mg/kg IP).”
“By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram).”
“These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.”
“ Ascorbic acid gradually increased the solubility of the haloperidol from that of the control where as cetrimide did not show any effect.”
“Recent reports have suggested an augmentation by ascorbic acid of haloperidol treatment of schizophrenic patients.”
“Furthermore, as previously shown for AsA in rats and monkeys, AsA (1000 mg/kg) potentiated the cataleptogenic effect of haloperidol (0.2 mg/kg, s.c.).”
Evidence for an action of araboascorbic acid on dopaminergic pathways of the corpus striatum“Apomorphine and haloperidol consistently decreased AA level as well.”
“In both areas, haloperidol only marginally affected the amphetamine-induced increase in ascorbic acid.”
“ Haloperidol (0.2 mg/kg) blocked the amphetamine-induced increase in UA but reduced the AA increase only by about 20%.”
“In both animal species pretreatment with ascorbic acid (1000 mg/kg) markedly potentiated catalepsy induced by haloperidol.”
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