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Last Updated: 2 years ago

Possible Interaction: Haloperidol and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

While haloperidol was significantly more effective than ascorbic acid , the combination was significantly more effective than either used alone.
The American journal of psychiatry  •  1987  |  View Paper
Catalepsy induced by haloperidol (0.25 mg/kg IP) was attenuated by ascorbic acid (50–200 mg/kg IP) while pentobarbitone (20 mg/kg IP)-induced sleep in rats was dose-dependently antagonised by ascorbic acid (50–400 mg/kg IP).
Psychopharmacology  •  2004  |  View Paper
By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram).
These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.
Science  •  1985  |  View Paper
Ascorbic acid gradually increased the solubility of the haloperidol from that of the control where as cetrimide did not show any effect.
Chemical & pharmaceutical bulletin  •  2001  |  View Paper
Recent reports have suggested an augmentation by ascorbic acid of haloperidol treatment of schizophrenic patients.
Journal of clinical psychopharmacology  •  1989  |  View Paper
Furthermore, as previously shown for AsA in rats and monkeys, AsA (1000 mg/kg) potentiated the cataleptogenic effect of haloperidol (0.2 mg/kg, s.c.).
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
Apomorphine and haloperidol consistently decreased AA level as well.
Pharmacological research  •  1991  |  View Paper
In both areas, haloperidol only marginally affected the amphetamine-induced increase in ascorbic acid.
Life sciences  •  1990  |  View Paper
Haloperidol (0.2 mg/kg) blocked the amphetamine-induced increase in UA but reduced the AA increase only by about 20%.
Pharmacology Biochemistry and Behavior  •  1987  |  View Paper
In both animal species pretreatment with ascorbic acid (1000 mg/kg) markedly potentiated catalepsy induced by haloperidol.
Pharmacology Biochemistry and Behavior  •  1986  |  View Paper
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