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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Haloperidol
supplement:
Tyrosine
Research Papers that Mention the Interaction
“In contrast, tyrosine (50 mg/kg) significantly prolonged the haloperidol (1 mg/kg) induced increase in striatal extracellular DA concentrations but had no effect in the MPFC.”
Tyrosine Augments Acute Clozapine- but not Haloperidol-Induced Dopamine Release in the Medial Prefrontal Cortex of the Rat: An in vivo Microdialysis Study“Additionally, exogenous tyrosine has been demonstrated to enhance the pharmacologically‐induced increase in dopamine metabolism seen following administration of haloperidol or the anxiogenic B‐carboline, FG‐7142.”
“Pretreatment with haloperidol or the partial lesioning of nigrostriatal neurons enhanced the effect of tyrosine on dopamine release, and haloperidol also prolonged this effect.”
“ Haloperidol (10-8M) caused a small, but significant increase in [3H]DA accumulation from [3H]tyrosine in the presence of 26 mM K+, possible reflecting blockade of presynaptic receptors activated by release DA.”
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