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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Haloperidol
supplement:
N-Acetylaspartate
Research Papers that Mention the Interaction
“The results indicate that the antipsychotic drugs haloperidol and clozapine increase both NAA and NAAG levels in SH‐SY5Y cells in a dose and time dependant manner, providing evidence that NAA and NAAG metabolism in neurons is responsive to antipsychotic drug treatment.”
Antipsychotic drugs increase N‐acetylaspartate and N‐acetylaspartylglutamate in SH‐SY5Y human neuroblastoma cells“Chronic administration of haloperidol was associated with a significant increase (+23%) in NAA in the striatum (p<0.05) when compared to controls, with no significant changes in the other regions investigated (frontal and temporal cortex, thalamus, hippocampus, amygdala, and nucleus accumbens).”
“ NAA appears to be selectively increased in the striatum of rats chronically receiving haloperidol.”
Increased N-acetylaspartate in rat striatum following long-term administration of haloperidol
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