Possible Interaction: Haloperidol and Calcium Supplement

“Calmodulin (CaM) antagonists, W-7 and W-5, chlorpromazine and haloperidol , especially W-7 inhibited 125I-bovine TSH binding to human and porcine thyroid receptors dose-dependently in the presence of calcium ion.”

“Co-incubation of cultures with a therapeutic dose of haloperidol blocked the beta-amyloid-induced elevation of calcium.”

“In this study, we report that it induced calcium ion influx via L-type calcium channels and that the elevation of calcium ions induced by haloperidol appeared to render hippocampal cells more susceptible to oxidative stress.”

“ Haloperidol decreased by ca.”

“These results show that the drugs that increase the influx of Ca ²⁺ into the cardiomyocyte decrease the negative inotropic effect of haloperidol , suggesting that the effect of haloperidol could be mediated via mechanisms involving actions on Ca²⁺ entry into the cardiomyocyte.”

“… haloperidol … Ca ²⁺ (E_max = 42.93 ± 3.22; EC₅₀ = 0.37 ± 0.07 µmol/l; pD’_2</… = 42.03 ± 3.72, EC₅₀ = 0.32 ± 0.05 µmol/l, pD’₂ = 6.81 ± 0.14).”

“The … haloperidol depends on preincubation conditions: … with preincubation time; Ca and Mg protect the enzyme against the effect of the drug: the inhibitory effect of haloperidol decreases upon increasing [Ca2'], … [Mg], and disappears at 20 mM [Mg] for any [Ca2+], and at 0.5 mM [Ca2+] for any [Mg2'].”

“These results suggest that haloperidol selectively inhibited signal transduction processes from activation of muscarinic acetylcholine receptors to influx of extracellular Ca and from activation of histamine H1-receptors to release of intracellularly stored Ca.”

“Imipramine, chlorpromazine and haloperidol in micromolar concentrations blocked sodium, calcium and potassium channel currents in a reversible and concentration-dependent manner.”

“Neuroleptics, particularly haloperidol and perphenazine, inhibit the activity of brain Ca , Mg-ATPase to a greater extent than the antidepressants benactizin and amphetamine.”