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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Haloperidol
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Systemic, intraventricular, or intraneostriatal ascorbate administration, for example, attenuates the behavioral effects of amphetamine and potentiates the behavioral response to haloperidol.”
A vitamin as neuromodulator: Ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission“Repeated haloperidol injections increase extracellular striatal ascorbate.”
Effects of long-term haloperidol treatment on glutamate-evoked ascorbate release in rat striatum.“Pretreatment with ascorbate , a modulator of dopamine transmission in the striatum, enhances the ability of haloperidol , a dopamine antagonist, to induce catalepsy and block the motor-activating effects of amphetamine.”
“Our results indicate that when challenged with the dopamine agonist, apomorphine (0.5 mg/kg), animals chronically treated with …-dose ascorbate alone display a supersensitive sniffing response relative to controls, while animals chronically treated with the combination of haloperidol … ascorbate display a further potentiation of … to the haloperidol groups.”
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