Possible Interaction: Guanosine and Inosine

“ Guanosine also increases extracellular inosine , uridine, thymidine, and cytidine, yet decreases extracellular uric acid.”

“Inosine, guanosine , 2'-deoxyadenosine, tubercidin, formycin B, and the pyrimidines uridine, thymidine, and cytidine (all 100 microM) inhibited transport of adenosine and inosine about 50-100%, while 3'-deoxyinosine showed weak inhibitory action.”

“Addition of adenosine, g anosine o r in osine c aused moderate to marked reduction in autohemolysis of nearly all types of red cells tested.”

“A reversal of their antiviral activity was observed after addition of guanosine , suggesting their involvement in the inhibition of the inosine monophosphate dehydrogenase enzyme (IMPDH).”

“Substitution of guanosines for inosines induces a reversal of the reduced dichroism from negative to positive.”

“Reduced catabolism was observed in the medium by enterocytes from fasted as compared to fed animals after 1 min of incubation with both inosine and guanosine.”

“Comparable inhibition of guanosine and adenosine transport by each other and by inosine support the hypothesis that guanosine and adenosine are transported by a common carrier.”

“The relative affinity of the antibodies for various nucleosides shows that inosine has a 180-fold higher affinity than guanosine, and that several inosine and guanosine analogues have at least a 4-fold lower affinity than guanosine.”

“UA … from guanosine … inosine in combination (GI mixture) as well as nucleosides increased time-dependently and almost linearly up to 2 h. Selecting GI mixture, effects of allopurinol, a widely used anti-hyperuricemic agent, and quercetin, a well-known polyphenol in onion and strawberry, on UA production were examined.”

“These results clearly indicate that the structural consequences of replacing a single guanosine with an inosine are transmitted over a significant distance.”