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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Urea
Research Papers that Mention the Interaction
“Its immunological reactivity survived exposure to 0.5 m urea, but was reduced by exposure to 6.0 m urea plus 0.4 m guanidine.”
Nicotinamide mononucleotide adenylyltransferase, a nonhistone chromatin protein. Immunochemical comparative studies.“Enzyme activity is also reversibly inhibited by urea at concentrations below 2 M. Guanidine at 0.15 M produces 50% inhibition of glucose formation from a phosphorylase limit dextrin.”
“3.|Concentrations of urea greater than 6 M and of guanidine above 0.5 M produce an irreversible denaturation resulting in a protein which is eluted earlier from a Sephadex column than the active enzyme.”
“They catalyze the hydrolysis of the guanidino group and produce urea.”
Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective.“The results reveal that guanidinium and urea synergistically enlarge the entropy difference of the redox couple and significantly increase the Seebeck effect.”
“ Guanidine and urea are seen to interact at several sites some of which are different in the two cases.”
“The inhibition by urea and guanidine has been found to be competitive in nature—a fact that has been supported by mixed inhibition study indicating the competition for the same site as that of the substrate.”
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