Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Guanidines and Threonine

supplement:

Guanidines

supplement:

Threonine

Research Papers that Mention the Interaction

In insulin, HisB5 → Thr markedly destabilizes the hormone ( ΔΔGu 2.0 ± 0.2 kcal/mol), impairs chain combination, and blocks cellular secretion of proinsulin.
The Journal of Biological Chemistry  •  2009  |  View Paper
Surprisingly, the introduction of a guanidine moiety always led to a decrease in THR inhibiting properties.
Bioorganic & medicinal chemistry letters  •  2006  |  View Paper