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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Guanidines
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“This finding suggests that TTX can interfere to a certain extent with the influx of guanidine into muscle fibers through sodium channels.”
Myonecrosis induced by guanidine in the mouse isolated phrenic nerve diaphragm preparation.“Neuronal cells exhibit a veratridine-stimulated (EC50 30 microM) guanidinium uptake , which is blocked by tetrodotoxin (IC50 30nM).”
“Alkyl and aromatic guanidines interact strongly with the tetrodotoxin (TTX)- receptor site in eel electroplaque membranes, showing competition with TTX.”
“From these results, it is concluded that tetrodotoxin and guanidine or methylguanidine would be antagonistic at the presynaptic site of sympathetic nerve ending.”
“In the hypogastric nerve-vas deferens preparation of the guinea-pig, the contractions of the vas deferens induced by the electrical … hypogastric nerve were suppressed after the administrations of crystalline tetrodotoxin 5×10-8M and procaine 10-4M, and the suppression by tetrodotoxin … guanidine 10-3M or … temporally antagonized.”
“The antagonistic phenomena between crystalline tetrodotoxin and guanidine in the sympathetic nerve-smooth muscle preparations were investigated and the following results were obtained.”
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