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Last Updated: 2 years ago

Possible Interaction: Guanidines and Streptozocin

supplement:

Guanidines

Research Papers that Mention the Interaction

STZ induced cellular DNA damage and apoptosis, and frequently initiated DNA modification at guanines , especially at the middle guanine in runs of three and at the guanine at the 3'-end of runs of two guanines, similar to N-methyl-N-nitrosourea, a typical methylating agent.
These results suggest that STZ induces DNA damage by methylation of guanines via methyl cations.
Biochemical pharmacology  •  1999  |  View Paper
In the present study, we observed that guanidine decreased plasma glucose in STZ rats, which was blocked by I2R antagonist (BU224) but not by opioid receptor antagonist (naloxone) or opioid-mu receptor antagonist (naloxonazine).
Neuroscience Letters  •  2009  |  View Paper
From this above in vivo and in vitro results, we conclude that, the cardio protective anti fibrotic activity of amino guanidine was mainly attributed by exhibiting the inhibitory efficacy against streptozotocin and high glucose induced collagen accumulation probably by inhibiting high glucose altered metalloproteinase-2 and -9 activities.
Chemico-biological interactions  •  2012  |  View Paper