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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Streptozocin
Research Papers that Mention the Interaction
“ STZ induced cellular DNA damage and apoptosis, and frequently initiated DNA modification at guanines , especially at the middle guanine in runs of three and at the guanine at the 3'-end of runs of two guanines, similar to N-methyl-N-nitrosourea, a typical methylating agent.”
“These results suggest that STZ induces DNA damage by methylation of guanines via methyl cations.”
Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin.“In the present study, we observed that guanidine decreased plasma glucose in STZ rats, which was blocked by I2R antagonist (BU224) but not by opioid receptor antagonist (naloxone) or opioid-mu receptor antagonist (naloxonazine).”
Activation of imidazoline I2B receptors by guanidine to increase glucose uptake in skeletal muscle of rats“From this above in vivo and in vitro results, we conclude that, the cardio protective anti fibrotic activity of amino guanidine was mainly attributed by exhibiting the inhibitory efficacy against streptozotocin and high glucose induced collagen accumulation probably by inhibiting high glucose altered metalloproteinase-2 and -9 activities.”
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