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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Phenoxybenzamine
Research Papers that Mention the Interaction
“ Guanidine enhanced moderately the field-stimulated release of [3H]NE from spleen strips pretreated with phenoxybenzamine.”
Structure-activity relationship between guanidine alkyl derivatives and norepinephrine release: site(s) and mechanism(s) of action.“Pretreatment with phenoxybenzamine prevented the uptake of the guanidiniums by the spleen and, as a result, they were not subsequently released on nerve stimulation.”
“When phenoxybenzamine was added to the perfusate after administration of the guanidiniums , proportionately more norepinephrine was released than guanethidine or bethanidine, but a straight line relationship between the output of norepinephrine and the guanidiniums was still apparent.”
The release of guanethidine and bethanidine by splenic nerve stimulation: a quantitative evaluation showing dissociation from adrenergic blockade.
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