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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs.”
N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors.“In contrast, the l-Arg guanidinium interacts more weakly and equally with both NO atoms, and an active-site water molecule hydrogen bonds to the distal NO oxygen.”
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation.“This indicates that the complex is stabilized by 14 kJmol–1 in the presence of substrate, consistent with a strong H-bonding interaction between NO and the guanidino group.”
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