Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“The results proved that the selective conversion of lysine to homoarginine by the guanidination could increase the sensitivity and selectivity of mass spectrum.”
Se pu = Chinese journal of chromatography • 2014 | View Paper
“Chemical modification of lysines by guanidination decreased heparin-neutralizing and binding activity, while modification of arginine residues had no effect.”
The Journal of biological chemistry • 1976 | View Paper
“Freebase guanidination effectively increases the dynamic range of detection of lysine-containing peptides while decreasing the work needed for sample preparation.”
“ Guanidination inactivated almost completely both activities and acetimidination at a very low degree (3 of 14 lysines ) led to less than 50% of both activities.”
“Each of the modified proteins has a single free amino group; the other amino groups of lysine or the amino terminus are blocked by acetylation or guanidination.”