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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Levofloxacin
Research Papers that Mention the Interaction
“Cellular accumulation of LVFX was inversely increased when guanidine suppressed the appearance of LVFX in the apical medium in a concentration-dependent manner.”
“ Guanidine trans-stimulated the efflux of LVFX from LLC-PK1 cells but did not affect cimetidine efflux.”
“ LVFX permeation in the basal-to-apical direction was significantly reduced in the presence of guanidine , enoxacin, and L-arginine, whereas tetraethylammonium, D-arginine, D- and L-lysine had no effect on the basal-to-apical permeation of LVFX.”
“These results imply that the inhibitory effect of guanidine on the basal-to-apical permeation of LVFX involves the permeation process across the apical membrane.”
Stereoselective permeation of new fluorinated quinolone derivatives across LLC-PK1 cell monolayers.
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