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Last Updated: 2 years ago

Possible Interaction: Guanidines and Levofloxacin

supplement:

Guanidines

Research Papers that Mention the Interaction

Cellular accumulation of LVFX was inversely increased when guanidine suppressed the appearance of LVFX in the apical medium in a concentration-dependent manner.
Guanidine trans-stimulated the efflux of LVFX from LLC-PK1 cells but did not affect cimetidine efflux.
LVFX permeation in the basal-to-apical direction was significantly reduced in the presence of guanidine , enoxacin, and L-arginine, whereas tetraethylammonium, D-arginine, D- and L-lysine had no effect on the basal-to-apical permeation of LVFX.
These results imply that the inhibitory effect of guanidine on the basal-to-apical permeation of LVFX involves the permeation process across the apical membrane.
Biological & pharmaceutical bulletin  •  1999  |  View Paper