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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Guanidines
drug:
Idazoxan
Research Papers that Mention the Interaction
“The specific binding of [3H]‐idazoxan (defined by cirazoline 0.1 mM) to membranes of human atrial appendages was concentration‐dependently inhibited by several imidazolines and guanidines , but not by rauwolscine and agmatine.”
Presynaptic imidazoline receptors and non‐adrenoceptor[3H]‐idazoxan binding sites in human cardiovascular tissues“… [3H]idazoxan … guanidines with the following rank order of potency which conforms to the characteristics of the previously defined I2-IBS (in parentheses: Ki, nmol/l): …-ylamino) isoindoline) > BDF 6100 (563; 2-(2-imidazolin-2-ylamino)-isoindoline) ≥ BDF 7579 (868; (4-chloro-2-isoindolinyl)guanidine) > phentolamine (1424) = naphazoline (1451).”
[3H]Idazoxan binding to bovine adrenal medullary membranes: identification and pharmacological characterization of I2-imidazoline sites“Specific binding of [3H]idazoxan is inhibited by compounds possessing an imidazoline or a guanidinium moiety whereas phenylethanolamines and classical alpha 2-antagonists are ineffective competitors which suggests an imidazoline-preferring binding site.”
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