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Last Updated: 2 years ago

Possible Interaction: Guanfacine and Yohimbine

supplement:

Yohimbine

Research Papers that Mention the Interaction

Atomoxetine and guanfacine reduced premature responses, while yohimbine bi-phasically affected this index of motor impulsivity.
Psychopharmacology  •  2021  |  View Paper
These effects of guanfacine were blocked by co-administered yohimbine , a non-selective α(2)-AR antagonist.
Molecular and Cellular Neuroscience  •  2012  |  View Paper
Yohimbine treatment during early withdrawal increased reinstatement to conditioned cues, while guanfacine treatment reduced reinstatement to yohimbine.
Psychopharmacology  •  2012  |  View Paper
Consistently, bath-application of guanfacine suppressed eEPSC in layer V/VI pyramidal neurons, and this effect was blocked by the alpha2-AR antagonist yohimbine or the Gi inhibitor NF023.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  •  2008  |  View Paper
Yohimbine (0.1 microM), a nonspecific alpha(2)-adrenoceptor antagonist caused a parallel shift to the right (1.2 log unit) in the concentration-response curve of guanfacine without depressing the maxima.
Pharmacological research  •  2006  |  View Paper
That noradrenaline was approximately 10 fold more potent than dopamine, that the dopamine response was not antagonised … (-)sulpiride, but was mimicked by the α2-agonist guanfacine and partially antagonised by the α2-adrenoceptor antagonist yohimbine (which … guanfacine ) would indicate that a component of … is effected via α2-adrenoceptor mechanisms.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The antikinesic action of guanfacine was antagonised completely by yohimbine (1 mg/kg), but not prazosin (1 mg/kg).
Journal of Neural Transmission  •  2003  |  View Paper
Naloxone (0.1 mg/kg) does not change, whereas prazosin and yohimbine (both on doses of 0.1 mg/kg) remove and partly relieve the depressant effect of guanfacine.
Eksperimental'naia i klinicheskaia farmakologiia  •  1997  |  View Paper
The effects of guanfacin were antagonized by idazoxan, yohimbine and RX821002 (all selective for alpha 2-adrenoceptors) but not prazosin (selective for alpha 1-adrenoceptors).
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity  •  1993  |  View Paper
The inhibitory effect of clonidine and guanfacine was antagonized by yohimbine.
Archives internationales de physiologie, de biochimie et de biophysique  •  1993  |  View Paper
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