Possible Interaction: Green Tea Extract and Epigallocatechin

“Significant Trp fluorescence quenching occurs on interaction of the green tea component, EGCG with HGC(c) accompanied by a red shift.”

“The concentration of methemoglobin was increased significantly when challenged with tea extracts , and EGC.”

“In contrast, intraduodenal administration of GTE resulted in increased plasma concentrations of epicatechin, epigallocatechin , epigallocatechin gallate in a dose‐dependent manner.”

“ GTP supplementation increased urinary epigallocatechin and epicatechin concentrations.”

“ GTP supplementation resulted in increased urinary epigallocatechin and epicatechin concentrations, liver glutathione peroxidase activity and femur bone mineral density, decreased urinary 8-hydroxy-2′-deoxyguanosine and urinary calcium levels, but no effect on serum estradiol and blood chemistry levels.”

“These data suggest that EGCG and EGC are capable of altering AhR transcription and are responsible for most, if not all, of the AhR antagonist activity of GTE.”

“Although cell proliferation was inhibited by (-)-epigallocatechin gallate and the tea extracts , there were only marginal effects on differentiation of DS19 cells as judged by hemoglobin synthesis.”

“Addition of (-)-epigallocatechin gallate (EGCG), an ingredient of green tea extract, to low concentration of green and black tea extracts substantially enhanced the scavenging of H2O2 and quenching of 8-OHdG, suggesting the important role of EGCG in the antioxidant activities of tea extracts.”