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“Further in vivo studies revealed the combinatorial diets of GTPs and BSp significantly inhibited breast tumor growth in ERα-negative mouse xenografts, especially when combined with TAM treatment.”
“Collectively, these studies indicate that combined GTPs and BSp are highly effective in inhibiting early breast cancer development by, at least in part, regulating epigenetic mechanisms.”
“Herein, we present an integrated DNA methylome and transcriptome analyses for defining the early-life epigenetic … BSp and GTPs on mammary tumors and our results indicate that a combinatorial administration of BSp … GTPs have a stronger impact at both transcriptome and … in comparison to BSp or GTPs administered alone.”