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Last Updated: 4 months ago

Possible Interaction: Gramicidin and Calcium Supplement

Research Papers that Mention the Interaction

Competition studies indicated that neither Na+ nor Ca2+ had a major effect on the stability of preformed heterodimers and that GS in fact out-competed Ca2+ and Na+ from Srf.
Journal of The American Society for Mass Spectrometry  •  2017  |  View Paper
It was found that calcium ions principally alter the relative composition of the equilibrium mixture of gramicidin conformers present in the solvent.
Thus, the binding of divalent calcium ions has a number of dramatic effects on the conformations of gramicidin present in solution.
European Biophysics Journal  •  1997  |  View Paper
The uptake of calcium was inhibited by the proton conducting ionophores carbonylcyanide m-chlorophenylhydrazone and Gramicidin-D. The accumulated calcium was freely exchangeable with external calcium and was rapidly released by the addition of inhibitors of energy transduction, proton-translocating uncouplers or the ionophore A23187.
European journal of biochemistry  •  1979  |  View Paper
Using ion-specific fluorescent probes, gramicidin D (1 microM) increased the intracellular concentrations of Na+ ([Na+]i) and Ca2+ ([Ca2+]i).
Biochemical and biophysical research communications  •  1995  |  View Paper
Gramicidin S (5 microM) decreases the slow outward transport system to 0.01 p mol cm-2 sec-1 and at concentrations greater than 1 microM inhibits not only slow magnesium outflux in low calcium Ringer but also inhibits magnesium influx during recovery of Mg2+ in Ringer.
Life sciences  •  1994  |  View Paper
The addition of calcium (0.05 mM) induced a reduction of single channel conductance of gramicidin A in DOPC- and mixed DOPC/ganglioside membranes.
Neurochemistry International  •  1992  |  View Paper
GS inhibited sarcolemmal Ca2+-stimulated ATPase (IC50 = 3 microM), Ca2+/Mg2+ ATPase which is activated by millimolar Ca2+ or Mg2+ (IC50 = 3.4 microM), and sarcoplasmic reticulum Ca2+-stimulated ATPase (IC50 = 6 microM).
Canadian journal of physiology and pharmacology  •  1989  |  View Paper
Gramicidin also induced a large increase in cytoplasmic calcium which was maximal within 0.5 min.
Molecular pharmacology  •  1988  |  View Paper
Macrocyclic antibiotics (valinomycin, tyrocidin, and gramicidin ) at relatively high concentration increased the rate of Ca release similarly to their effects on fragmented sarcoplasmic reticulum membranes.
Archives of biochemistry and biophysics  •  1971  |  View Paper