Possible Interaction: Gossypol and Vitamin E

“Gossypol significantly increased the levels of malondialdehyde (P < 0.01), a lipid peroxidation indicator, whereas treatment with vitamin E inhibited the action of the gossypol.”

“ Vitamin E prevented a decrease in mitochondrial ATP induced by gossypol (P < 0.05).ConclusionsThis study suggests that the reproductive dysfunction caused by gossypol may be related to oxidative stress and mitochondrial bioenergetic damage and that treatment with vitamin E can prevent the infertility caused by the toxin.”

“Feeding cottonseed meal caused death of some calves with gossypol related toxicity signs, but did not decrease plasma alpha-tocopherol; however, vitamin E supplementation increased performance and may have conferred some protection against gossypol toxicity.”

“ Vitamin E supplementation in bulls that received gossypol improved the number of mounts in the first test and the time to first service in the second test.”