Possible Interaction: Gossypol and Substance P

“ Gossypol almost abolished the effects of acetylcholine and substance P on vascular resistance, but had no significant effect on the responses to prostaglandin E1 and glyceryl trinitrate.”

“Furthermore, pre-incubation with gossypol , an inhibitor of the formation and release of endothelium-derived relaxing factors (EDRF), completely abolished the effects of SP without influencing the dilatory action of CGRP.”

“The in vivo blood pressure lowering effect of three vasodilators whose in vitro effects are endothelium-dependent (acetylcholine, substance P and adenosine triphosphate) was reduced by 40-60% after systemic treatment of the animals with gossypol.”

“3 A 20 min … endothelium‐intact strips to gossypol , an irreversible inhibitor of the production and/or release of endothelium‐derived …, abolished vasodilatation in response to the endothelium‐dependent agents acetylcholine and substance P , did not change relaxations to prostaglandin E1, but … enhanced relaxations in response to glyceryl trinitrate.”

“After gossypol , the flow responses to the endothelium-dependent compounds (ACh, ATP, and SP ) were severely reduced (by 88 +/- 3%, P less than 0.01) or sometimes were converted to constrictions (ATP).”

“The selective action of gossypol in suppressing the flow responses to the endothelium-dependent compounds ACh, ATP, and SP is consistent with a vasomotor role for endothelial cells in resistance-sized vessels in vivo.”