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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Background Our previous studies suggested that low‐dose gossypol combined with steroid hormones has a reversible antifertility role in adult male rats, and the course of treatment was shorter than that of either gossypol or steroid hormones alone.”
“Combined use of low‐dose gossypol and steroid hormones played a comprehensive antifertility role in their synergistic effect on reducing the number and motility of epididymal sperm.”
“This result suggested that low‐dose gossypol and steroid hormones have a drug synergistic effect on antifertility.”
Drug synergistic antifertility effect of combined administration of low‐dose gossypol with steroid hormones in rats“In order to reduce the side effect of gossypol, gossypol was used in combination with steroid hormones so that the dose of both drugs can be reduced.”
“Serum testosterone and estradiol-17 beta levels imply that gossypol can reduce steroid hormonal levels.”
“These observations imply that gossypol and steroid hormones can interact to alter prostate development and gossypol metabolism and/or clearance.”
“A more pronounced inhibitory effect was observed upon 11 beta-hydroxylation of steroids ; I50 was 11 microM. Seventy-five percent of corticosterone production was impaired when 30 microM of gossypol were present.”
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