supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gossypol
Research Papers that Mention the Interaction
“The steroidogenic response of granulosa cells to hCG was inhibited by (+/-) gossypol at 10 and 30 micrograms.ml-1.”
[Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats].“The present experiment indicates that gossypol acetic acid can inhibit the progesterone production stimulated by hCG in isolated rat luteal cells through direct cellular mechanism.”
“At 10 micrograms/ml, gossypol significantly inhibited hCG- and forskolin-stimulated progesterone secretion and intracellular cAMP formation; at 20 micrograms/ml, gossypol completely abolished the stimulative effect of hCG and forskolin.”
“It is postulated that the blockade of gonadotrophic effect of hCG may be the chief mechanism by which gossypol acetic acid interrupts early pregnancy in female rats.”
“When the in vitro release of T from the rat testes mince in the presence of hCG and gossypol was evaluated, an inhibiton of T release was recorded.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback