Possible Interaction: Gossypol and Progesterone

“ Gossypol enhanced the nitrite content in culture media of SGC and inhibited basal progesterone secretion by SGC.”

“Moreover, gossypol inhibited forskolin-stimulated progesterone secretion, as well as substrate-enhanced conversion of 22-OH-cholesterol and pregnenolone to progesterone.”

“These results suggest that the inhibitory effect of gossypol on progesterone secretion in culture of SGC may be mediated via NO generation.”

“The activities of 3 beta-HSD, adenyl cyclase and hCG-stimulated progesterone production were inhibited by higher concentrations of gossypol. (”

“Those results indicate that gossypol might block progesterone action which is inhibitory against MAO activity.”

“Study demonstrated that gossypol significantly (P<0.001) inhibited granulosa cell estradiol 17beta and progesterone production, an effect that could be at least partially mediated by an increase (P<0.05) of nitric oxide and superoxide anion production as a consequence of superoxide dismutase inhibition.”

“The inhibitory effect of gossypol on cumulus expansion of OCC was accompanied by inhibition of progesterone secretion of OCC and the decrease of [125I]EGF binding to granulosa cells.”

“ GP and GN significantly suppressed Progesterone (P4) and Estradiol (E2) release in a dose-dependent manner, respectively.”

“ Gossypol significantly inhibited the conversions of exogenous 25-OH cholesterol and pregnenolone to progesterone.”

“ Gossypol , at 17-34 microM, inhibited dbcAMP-induced progesterone secretion.”

“The present study investigated some possible sites subsequent to cAMP formation at which gossypol may inhibit progesterone biosynthesis.”

“These results suggest that gossypol inhibits progesterone synthesis in bovine luteal cells by suppressing steroidogenic enzyme activity.”