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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gossypol
drug:
Paclitaxel
Research Papers that Mention the Interaction
“Gossypol did not directly suppress the binding of NF-κB to the DNA but rather inhibited … translocation of p65 and p50 via phosphorylation and degradation of IκB. We also found that gossypol suppresses NF-κB activation induced by … wide variety of agents, including taxol , okadaic acid, and … myristate acetate.”
Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity.“Our data showed that treatment of Ramos cells with gossypol not only induced cell arrest on the G0/G1 phase, but also augmented apoptosis and growth inhibition induced by etoposide (VP-16), doxorubicin hydrochloride (ADM), vincristine (VCR), and paclitaxel (taxol).”
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