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Last Updated: 2 years ago

Possible Interaction: Gossypol and NAD

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supplement:

Gossypol

supplement:

NAD

Research Papers that Mention the Interaction

“For the conversion of pyruvate to lactate the IC50 for … the reverse reaction the IC50 is 12 microM. Gossypol is a competitive inhibitor … (Km = 17 microM), and NAD+ , Ki = 6 microM (Km = 130 microM), and noncompetitive for pyruvate, Ki = … microM), and lactate, Ki = 52 microM (Km = 5.6 mM).”

Kinetics of gossypol inhibition of bovine lactate dehydrogenase X.

Biochemical and biophysical research communications • 1983 | View Paper

“ Gossypol , a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease.”

Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi.

Science • 1982 | View Paper

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