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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gossypol
Research Papers that Mention the Interaction
“Also, following administration of gossypol (12.5 mg/kg/day) for 6 weeks, sperm motility, HAM and rate of fertilization in … hamster cauda epididymal spermatozoa were significantly decreased and the extracts of testis delayed dispersion of the cumulus oophorus cells, suggesting that hyaluronidase and other acrosomal … inhibited by gossypol.”
Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity.“ Hyaluronidase , β‐glucuronidase, and acid phosphatase were inhibited only at a higher concentration of gossypol (380 μM).”
“ Gossypol produced a significant decrease in hyaluronidase and sorbitol dehydrogenase, while no change was observed in beta-glucuronidase and acid phosphatase.”
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