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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gossypol
drug:
Dihydrotestosterone
Research Papers that Mention the Interaction
“At 200 microM concentration, gossypol significantly decreased dihydrotestosterone ( DHT ) formation by 21% when compared to that of control (0.6 pm/mg protein/min), and decreased 5 alpha-androstane-3 alpha,17 beta-diol formation by 35% vs control (2 pm/mg protein/min).”
“In the current study, gossypol was found to have inhibitory effects of noncompetitive nature on 5 alpha-reductase, which catalyzes the conversion of testosterone to DHT , and on 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), which interconverts DHT and dihydroandrostanediol.”
Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes.
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