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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Previously, we have shown that AA inhibited stimulated release of luteinizing hormone-releasing hormone (LHRH) from medial basal hypothalami in vitro.”
Inhibition of Stimulated Ascorbic Acid and Luteinizing Hormone-Releasing Hormone Release by Nitric Oxide Synthase or Guanyl Cyclase Inhibitors“Because high concentrations of ascorbic acid (AA) are found in the adenohypophysis, we hypothesized that it might have an acute … secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the gland, particularly because we have reported that AA rapidly … LH-releasing hormone (LHRH) release from … hypothalamic explants.”
“ AA (10(-5) to 10(-3) M) had no effect on basal LH-RH release but completely blocked high [K(+)]- and nitroprusside-induced LH-RH release.”
“ AA (10(-5) to 10(-3) M) inhibited the LH-RH-releasing action of NMDA.”
“ AA may be an inhibitory neurotransmitter that blocks NOergic stimulation of LH-RH release by chemically reducing the NO released by the NOergic neurons.”
“The interval for maximum induction of ascorbic acid …-I was not seen until 48 h. GnRH (1 microM), phorbol ester (…; 1 mM) also induced ascorbic acid transport by 1.7-, 1.9-, and 2.3-fold (P < 0.… and 8Br-cAMP was synergistic (4.8-fold; P < 0.05).”
“Although it is assumed that ascorbate merely prevents the oxidative degradation of catecholamines, we have discovered that ascorbic acid itself produces significant increases in the release of LHRH.”
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