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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Treatment of cells with the RARα/RXRα ligands, all‐trans retinoic acid and 9‐cis‐retinoic acid, reduced and increased GnRH II gene expression in TE671 and JEG‐3 cells, respectively.”
Involvement of NF‐κB subunit p65 and retinoic acid receptors, RARα and RXRα, in transcriptional regulation of the human GnRH II gene“These results suggest that RA affects the expression of LHRH mRNA and the level of LHRH protein in SK-N-SH cells.”
“During a short-term period (2h), RA (0.01-1 microM) increased GnRH release in a dose-related manner.”
“In a long term (up to 48 h), RA increased GnRH mRNA levels in a dose- and time-related manner.”
“Significant increase in GnRH mRNA levels by RA (at higher than 10 nM) was observed within 12h.”
“Taken together, the present study strongly suggests that RA is an important regulator of the GnRH neurons.”
“Time-course experiments showed that RA rapidly increased GnRH release by 30 min in both cells.”
Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragments and GT1-1 neuronal cells in vitro.
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