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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
Research Papers that Mention the Interaction
“It has been shown that GnRH may have a direct effect on the ovary, as the addition of GnRH to granulosa cell cultures inhibits the production of progesterone and oestradiol.”
Is there a difference in the function of granulosa-luteal cells in patients undergoing in-vitro fertilization either with gonadotrophin-releasing hormone agonist or gonadotrophin-releasing hormone antagonist?“In women, progesterone suppresses luteinizing hormone (LH) ( gonadotropin‐releasing hormone ) pulse frequency, but how rapidly this occurs is unknown.”
“ LHRH also stimulated a significant increase in FSH levels after both alcohol and placebo intake during the follicular and luteal phases of the menstrual cycle (P less than .0001).”
“Plasma prolactin levels also increased significantly after LHRH administration during the follicular and luteal phases of the menstrual cycle (P less than .0001).”
“We conclude that progesterone slows the frequency of LH pulsatility by increasing endogenous opioid activity in the hypothalamus which may in turn inhibit the firing rate of the GnRH neurons.”
“Exogenously administered oestradiol or progesterone was found to induce augmentation of LH and FSH release in response to LHRH administration in patients with the polycystic ovary (PCO) syndrome.”
“Nevertheless differences in recovery rates after GnRH treatment in animals with either luteal or follicular cysts are reported.”
Reproductive performance of dairy cows with luteal or follicular ovarian cysts after treatment with buserelin.“Therefore, strategies to stimulate CL function using multiple doses of GnRH during the luteal phase need to consider potential negative effects.”
“The gonadal steroids estradiol and progesterone exert critical suppressive and stimulatory actions upon the brain to control gonadotropin-releasing hormone ( GnRH ) release that drives the estrous/menstrual cycle.”
“In sheep, progesterone inhibits GnRH pulse frequency by stimulating dynorphin release, and estradiol inhibits pulse amplitude by suppressing kisspeptin.”
“We review evidence for the specific neuronal pathways hypothesised to mediate progesterone negative feedback to GnRH neurons, and discuss the potential mechanisms by which androgens may evoke disruptions in these circuits at different developmental time points.”
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