Possible Interaction: Gonadotropin-Releasing Hormone and Potassium

“Cell membrane depolarization induced by increased potassium concentration [K(+)] increased medium concentrations of both AA and LH-RH.”

“ Potassium challenge (56 mM KCl) significantly stimulated LHRH release from the ME of both intact and castrate male rats suggesting that all tissues were able to respond to a stimulus, and that castration did not alter the responsiveness of the LHRH neuron to a nonspecific secretagogue.”

“Stimulation with potassium (80 mM) induced an equally strong release of PGE2 and LHRH from the MEs of both fed and starved rats.”

“This suggested that the mechanism responding to potassium may be contained within the stimulatory pathway of GnRH.”

“Depolarizing agents such as potassium (K+) or veratridine stimulated LHRH and SRIF release in a dose-dependent manner.”

“Basal release rate of LHRH is t° and calcium dependent, as is the stimulatory action of potassium.”

“Membrane depolarization produced by increasing the medium potassium concentration to 60 mM increased GnRH release to 200-500% of control.”

“Glands made refractory to LH-RH showed a decreased response to potassium and, conversely, the release of LH in response to LH-RH was reduced after exposure of glands to potassium.”

“High potassium stimulated the release of LH and enhanced the response of LH-RH.”

“Ahigh potassium concentration (56mM) induces an increase in LHRH release from entire pieces of mediobasal hypothalamus (MBH), but not from a synaptosomal pellet; this release is inhibited when calcium is omitted.”