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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gonadotropin-Releasing Hormone and Phosphatidic Acid

Research Papers that Mention the Interaction

It is concluded that activation of PLD and the resultant production of PA could mediate the antidifferentiative action of GnRH in preantral granulosa cells.
Endocrinology  •  1994  |  View Paper
By contrast, the levels of the 32P-prelabeled phosphatidylinositol and phosphatidic acid were increased at 5 min by PGF2 alpha or LHRH.
Endocrinology  •  1986  |  View Paper
In cultures of rat granulosa cells, luteinizing hormone-releasing hormone LHRH ) increases 32P incorporation into both phosphatidylinositol (PI) and phosphatidic acid (PA).
Canadian journal of physiology and pharmacology  •  1985  |  View Paper
In a 4-fold enriched population of gonadotrophs, 30 nM LHRH increased 32Pi incorporation into phosphatidic acid (PA) as early as 1 min after its addition.
Molecular and Cellular Endocrinology  •  1984  |  View Paper
GnRH agonist in concentrations of 10(-9) to 10(-7)M increased phosphatidic acid labeling 292 +/- 16% (mean +/- SE), and phosphatidylinositol labeling 258 +/- 13.2%.
Journal of andrology  •  1984  |  View Paper
These results indicate that phospholipids, in particular phosphatidylinositol and phosphatidic acid , might be involved in the mechanism by which GnRH exerts its gonadal effects.
Endocrinology  •  1982  |  View Paper