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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidic Acid
Research Papers that Mention the Interaction
“It is concluded that activation of PLD and the resultant production of PA could mediate the antidifferentiative action of GnRH in preantral granulosa cells.”
Role of phospholipase-D and phosphatidic acid in mediating gonadotropin-releasing hormone-induced inhibition of preantral granulosa cell differentiation.“By contrast, the levels of the 32P-prelabeled phosphatidylinositol and phosphatidic acid were increased at 5 min by PGF2 alpha or LHRH.”
“In cultures of rat granulosa cells, luteinizing hormone-releasing hormone LHRH ) increases 32P incorporation into both phosphatidylinositol (PI) and phosphatidic acid (PA).”
“In a 4-fold enriched population of gonadotrophs, 30 nM LHRH increased 32Pi incorporation into phosphatidic acid (PA) as early as 1 min after its addition.”
“ GnRH agonist in concentrations of 10(-9) to 10(-7)M increased phosphatidic acid labeling 292 +/- 16% (mean +/- SE), and phosphatidylinositol labeling 258 +/- 13.2%.”
“These results indicate that phospholipids, in particular phosphatidylinositol and phosphatidic acid , might be involved in the mechanism by which GnRH exerts its gonadal effects.”
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