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Last Updated: 2 years ago

Possible Interaction: Gonadotropin-Releasing Hormone and Oxytocin

Research Papers that Mention the Interaction

GnRH caused a significant decrease in the maximal contraction intensity of nonpregnant and pregnant uterine muscle strip, following the action of oxytocin and acetylcholine.
Archives of Gynecology and Obstetrics  •  2006  |  View Paper
Additionally the increased LH levels observed in the peripheral circulation of pentobarbitone-anaesthetised rats administered GnRH were enhanced if the rats received oxytocin prior to the GnRH.
Incubation of pituitary pieces with oxytocin plus GnRH induced secretion of amounts of LH greater than the sum of the amounts released by oxytocin and GnRH separately.
Thus oxytocin synergised with GnRH in stimulating LH release.
Archives of physiology and biochemistry  •  2002  |  View Paper
NE, GA and oxytocin stimulate LHRH release by activation of neural nitric oxide synthase (nNOS).
Neuroimmunomodulation  •  1998  |  View Paper
Using qRT-PCR, we found that oxytocin treatment increased Gnrh mRNA levels in both the PH and AH.
Journal of Molecular Neuroscience  •  2017  |  View Paper
It has been delineated that oxytocin stimulates GnRH release from the rat hypothalamic explants and intranasal applied oxytocin up-regulates GnRH expression in the male rat hypothalamus.
Medical hypotheses  •  2017  |  View Paper
Intracerebroventricular (icv) infusion (experiment in vivo) of a GnRH antagonist resulted in substantial inhibition of OT release, thus revealing the stimulatory action of endogenous GnRH.
The results show that the highly selective GnRH agonist (i.e., [Des-Gly(10),d-His(Bzl)(6),Pro-NHEt(9)]-LHRH; Histrelin) stimulates the secretion of OT from an isolated rat H-N system.
Brain Research Bulletin  •  2010  |  View Paper
The administration of an oxytocin antagonist for 6 d to immature female rats decreased GnRH pulse frequency ex vivo and delayed the age at vaginal opening and first estrus.
Endocrinology  •  2008  |  View Paper
Together, these data suggest that oxytocin may directly control neuronal activity in a subpopulation of GnRH neurones.
Journal of neuroendocrinology  •  2007  |  View Paper
Recent studies from our laboratory have demonstrated that oxytocin induces dose‐dependent release of GnRH from proestrous basal hypothalamus explants.
Journal of neuroendocrinology  •  2004  |  View Paper
The ability of OT (10–15–10–9M) to stimulate the release of GnRH was determined in both ME and BH explants on PE and DI.
Neuroendocrinology  •  2001  |  View Paper
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