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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gonadotropin-Releasing Hormone and Masoprocol

Research Papers that Mention the Interaction

H-7 (10(-3)M, 10(-4)M and 10(-5)M) and NDGA (10(-3)M, 10(-4)M and 10(-5)M) significantly inhibited (P < 0.05) the effect of GnRH agonist on progesterone and estradiol production by the granulosa cells.
Endocrine journal  •  1998  |  View Paper
Furthermore, the gonadotrophin release by 1 nM GnRH was inhibited by nordihydroguaiaretic acid (a lipoxygenase inhibitor) with an IC50 of about 5 microM. Thus, the hydroperoxy (but not hydroxy) products of 12-lipoxygenase may be involved in the release of pituitary hormones especially LH and FSH.
The Journal of endocrinology  •  1996  |  View Paper
In contrast, pretreatment with the lipoxygenase inhibitor nordihydroguaiaretic acid decreased the total LH response to GnRH by 60%, reduced the magnitude and latency of the first LH peak, and shortened the duration of the response.
Endocrinology  •  1987  |  View Paper