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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Masoprocol
Research Papers that Mention the Interaction
“H-7 (10(-3)M, 10(-4)M and 10(-5)M) and NDGA (10(-3)M, 10(-4)M and 10(-5)M) significantly inhibited (P < 0.05) the effect of GnRH agonist on progesterone and estradiol production by the granulosa cells.”
Effects of GnRH on protein kinase C activity, Ca2+ mobilization and steroidogenesis of human granulosa cells.“Furthermore, the gonadotrophin release by 1 nM GnRH was inhibited by nordihydroguaiaretic acid (a lipoxygenase inhibitor) with an IC50 of about 5 microM. Thus, the hydroperoxy (but not hydroxy) products of 12-lipoxygenase may be involved in the release of pituitary hormones especially LH and FSH.”
Arachidonate 12-lipoxygenase in porcine anterior pituitary cells: its localization and possible function in gonadotrophs.“In contrast, pretreatment with the lipoxygenase inhibitor nordihydroguaiaretic acid decreased the total LH response to GnRH by 60%, reduced the magnitude and latency of the first LH peak, and shortened the duration of the response.”
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